Characterization ofpncAMutations of Pyrazinamide-ResistantMycobacterium tuberculosisin Korea
نویسندگان
چکیده
منابع مشابه
Characterization of pncA mutations of pyrazinamide-resistant Mycobacterium tuberculosis in Korea.
Mutations in the pyrazinamidase (PZase) gene (pncA) are considered the major mechanism of pyrazinamide (PZA) resistance in Mycobacterium tuberculosis. The aim of this study was designed to determine pncA mutations among ten PZA resistant and two PZA susceptible M. tuberculosis strains from Turkey and also to compare the PZase activity of them with the genotype. All isolates were identified by B...
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Pyrazinamide (PZA) is a first-line drug for short-course tuberculosis therapy. Resistance to PZA is usually accompanied by loss of pyrazinamidase (PZase) activity in Mycobacterium tuberculosis. PZase converts PZA to bactericidal pyrazinoic acid, and the loss of PZase activity is associated with PZA resistance. The gene (pncA) encoding the M. tuberculosis PZase has recently been sequenced, and m...
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INTRODUCTION Pyrazinamide (PZA) is an important first-line antituberculous drug, which is applied together with INH, RMP, EMB and SM. This drug plays a unique role in the first phase of TB therapy because it is active within macrophages and kills tubercule bacilli. Testing of the resistibility of Mycobacterium tuberculosis to PZA is technically difficult because PZA is active only at acid pH. T...
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The objective of this study was to compare the steady-state plasma and intrapulmonary concentrations of orally administered pyrazinamide in normal volunteers and subjects with AIDS. Pyrazinamide was administered at 1 g once daily for 5 days to 40 adult volunteers (10 men with AIDS, 10 normal men, 10 women with AIDS, and 10 normal women). Subjects with AIDS and with more than four stools per day...
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ژورنال
عنوان ژورنال: Journal of Korean Medical Science
سال: 2001
ISSN: 1011-8934,1598-6357
DOI: 10.3346/jkms.2001.16.5.537